3,4-Hexanedione

Available forms:clear yellow liquid

pd_proNo:474016-68584b74-5efc-45db-92f7-de179acc3eb3

pd_productuse:

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Detailed introduction

3,4-Hexanedione GMP Manufacturer Global Trade 4437-51-8 with Fast Delivery

  • Molecular Formula:C6H10O2
  • Molecular Weight:114.144
  • Appearance/Colour:clear yellow liquid 
  • Vapor Pressure:9.91mmHg at 25°C 
  • Melting Point:-10 °C 
  • Refractive Index:n20/D 1.41(lit.)  
  • Boiling Point:130 °C at 760 mmHg 
  • Flash Point:32.8 °C 
  • PSA:34.14000 
  • Density:0.936 g/cm3 
  • LogP:0.94460 

3,4-Hexanedione(Cas 4437-51-8) Usage

Preparation

By condensation of ethyl propionate in the presence of sodium metal, followed by oxidation of the resulting propionin with copper acetate or ferric chloride.

Biochem/physiol Actions

Odor at 1.0%

Aroma threshold values

Aroma characteristics at 1.0%: sweet buttery, creamy, slightly cooked caramel and burnt sugary reminiscent of ghee and eggy vanillas.

Taste threshold values

Taste characteristics at 5 ppm: sweet buttery, creamy, pound cake and egg caramel-like with vanilla nuances.

General Description

The dermal irritation and sensitization potential of 3,4-hexanedione (used as constituents of synthetic flavoring agent) was studied using a murine model. The 3,4-hexanedione derivatives inhibited oxoglutarate transport.

InChI:InChI=1/C6H10O2/c1-3-5(7)6(8)4-2/h3-4H2,1-2H3

4437-51-8 Relevant articles

Study on the synthesis of 1,2-diketones

Liu, Peng,Zhang, Yu-Mei,Zhang, Hong-Li

, p. 266 - 267 (2010)

A novel method is discussed for preparat...

-

Hobday,Short

, p. 612 (1943)

-

Sol-gel synthesis of ceria-zirconia-based high-entropy oxides as high-promotion catalysts for the synthesis of 1,2-diketones from aldehyde

Dinjar, Kristijan,Djerdj, Igor,Koj?inovi?, Jelena,Kukovecz, ákos,Markovi?, Berislav,Mileti?, Aleksandar,Nagy, Sándor Balázs,Sapi, Andras,Stenzel, David,Széchenyi, Aleksandar,Szenti, Imre,Tang, Yushu,Tatar, Dalibor,Varga, Gábor,Ziegenheim, Szilveszter

, (2021/10/20)

Efficient Lewis-acid-catalyzed direct co...

Synthesis Method of 3,4-hexanedione

-

Paragraph 0017; 0019; 0022; 0025, (2018/12/04)

A synthesis method of 3,4-hexanedione co...

Silver-Catalyzed Decarboxylative Couplings of Acids and Anhydrides: An Entry to 1,2-Diketones and Aryl-Substituted Ethanes

Zou, Hua-Xu,Li, Yang,Yang, Yuan,Li, Jin-Heng,Xiang, Jiannan

supporting information, p. 1439 - 1443 (2018/02/26)

Silver-catalyzed oxidative decarboxylati...

Heterogenization of ketone catalyst for epoxidatio by low pressure plasma fluorination of silica gel supports

D'Accolti, Lucia,De Vietro, Nicoletta,Fanelli, Fiorenza,Fusco, Caterina,Nacci, Angelo,Fracassi, Francesco

, (2018/01/03)

Low pressure plasma was used for prepari...

4437-51-8 Process route

propionaldehyde
123-38-6

propionaldehyde

propioin
4984-85-4

propioin

3,4-hexanedione
4437-51-8

3,4-hexanedione

Conditions
Conditions Yield
With Ce0.2Zr0.2La0.2Pr0.2Y0.2O2; benzoic acid; In acetonitrile; Overall yield = 68 percent; Schlenk technique; Reflux;
hex-3-yne
928-49-4

hex-3-yne

3,4-hexanedione
4437-51-8

3,4-hexanedione

dipropionyl peroxide
3248-28-0

dipropionyl peroxide

propionic acid anhydride
123-62-6

propionic acid anhydride

Conditions
Conditions Yield
With ozone; In dichloromethane; at -75 ℃; Yields of byproduct given;
10%

4437-51-8 Upstream products

  • 4984-85-4
    4984-85-4

    propioin

  • 19700-96-0
    19700-96-0

    hexa-1,5-diene-3,4-diol

  • 22520-39-4
    22520-39-4

    (3S,4R)-hexane-3,4-diol

  • 928-49-4
    928-49-4

    hex-3-yne

4437-51-8 Downstream products

  • 123-62-6
    123-62-6

    propionic acid anhydride

  • 39081-91-9
    39081-91-9

    2,5-dibromo-3,4-hexanedione

  • 802294-64-0
    802294-64-0

    propionic acid

  • 858212-73-4
    858212-73-4

    propionic acid-(1-ethyl-2-oxo-butylidenehydrazide)

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