Acetylpyrazine

Available forms:Light yellow to yellow-brownish powder

pd_proNo:539316-47a7a8ce-d482-4788-8682-89aa5c4076ca

pd_productuse:

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Detailed introduction

Quality Factory Hot Selling Acetylpyrazine 22047-25-2 with Fast Shipping

  • Molecular Formula:C6H6N2O
  • Molecular Weight:122.126
  • Appearance/Colour:Light yellow to yellow-brownish powder 
  • Vapor Pressure:0.095mmHg at 25°C 
  • Melting Point:75-78 °C 
  • Refractive Index:1.518 
  • Boiling Point:212.9 °C at 760 mmHg 
  • PKA:0.30±0.10(Predicted) 
  • Flash Point:84.4 °C 
  • PSA:42.85000 
  • Density:1.136 g/cm3 
  • LogP:0.67920 

Acetylpyrazine(Cas 22047-25-2) Usage

Preparation

synthesis of acetylpyrazine: By the ester condensation of EtO2 C-pyrazine; by dehydrating pyrazynamide with POCI3 and then reacting the resulting 2-cyano-pyrazine with methyl magnesium bromide.

Definition

ChEBI: 2-acetylpyrazine is a pyrazine that is substituted by an acetyl group at position 2. It has been identified as one of the volatile flavor constituents in popcorn, bread crust, vinegar, and potato snacks. It has a role as a flavouring agent. It is an aromatic ketone and a member of pyrazines.

Application

Acetylpyrazine has been widely used as an intermediate in the organic synthesis of various heterocyclic derivatives and in coupling reactions, alkylation reactions, and sensitizer ligands because of its good biological and reactive activities. For example, it is a significant reaction intermediate for producing drugs for treating malaria, epilepsy, and Parkinson's disease.

Aroma threshold values

Detection at 62 ppb

Taste threshold values

Taste characteristics at 10 ppm: roasted, nutty, bready, yeasty with popcorn, corn chip nuance

General Description

2-Acetylpyrazine has been identified as one of the volatile flavor constituents in popcorn, wheat and rye bread crust.

InChI:InChI=1/C6H8N2O/c1-6(9)8-4-2-7-3-5-8/h2-5,7H,1H3

22047-25-2 Relevant articles

Novel thiosemicarbazones derived from formyl- and acyldiazines: Synthesis, effects on cell proliferation, and synergism with antiviral agents

Easmon,Heinisch,Holzer,Rosenwirth

, p. 3288 - 3296 (1992)

The synthesis of a series of novel thios...

Comparison of pyrazines formation in methionine/glucose and corresponding Amadori rearrangement product model

Cui, Heping,Deng, Shibin,Hayat, Khizar,Ho, Chi-Tang,Zhai, Yun,Zhang, Qiang,Zhang, Xiaoming

, (2022/03/07)

The generation of pyrazines in a binary ...

Highly chemoselective deoxygenation of N-heterocyclic: N -oxides under transition metal-free conditions

Kim, Se Hyun,An, Ju Hyeon,Lee, Jun Hee

supporting information, p. 3735 - 3742 (2021/05/04)

Because their site-selective C-H functio...

Method for synthesizing 2-acetyl pyrazine

-

Paragraph 0022-0029, (2019/06/27)

The invention relates to the field of ch...

Iron-catalyzed Minisci acylation of N-heteroarenes with α-keto acids

Wang, Xiu-Zhi,Zeng, Cheng-Chu

supporting information, p. 1425 - 1430 (2019/02/01)

An efficient and mild protocol has been ...

22047-25-2 Process route

L-serin
56-45-1,83245-15-2

L-serin

L-lysine
56-87-1,3506-25-0

L-lysine

D-glucose
50-99-7

D-glucose

1,4-pyrazine
290-37-9

1,4-pyrazine

2-Methylpyrazine
109-08-0

2-Methylpyrazine

2,5-dimethyl-pyrazine
123-32-0

2,5-dimethyl-pyrazine

2,3-dimethylpyrazine
5910-89-4

2,3-dimethylpyrazine

acetylpyrazine
22047-25-2

acetylpyrazine

2-ethyl-3,6-dimethylpyrazine
13360-65-1

2-ethyl-3,6-dimethylpyrazine

2,6-dimethylpyrazine
108-50-9

2,6-dimethylpyrazine

2,3,5-trimethylpyrazine
14667-55-1

2,3,5-trimethylpyrazine

2-ethyl-6-methylpyrazine
13925-03-6

2-ethyl-6-methylpyrazine

2-ethyl-5-methypyrazine
13360-64-0

2-ethyl-5-methypyrazine

Conditions
Conditions Yield
In water; at 130 ℃; for 2h; pH=8;
L-lysine
56-87-1,3506-25-0

L-lysine

D-glucose
50-99-7

D-glucose

1,4-pyrazine
290-37-9

1,4-pyrazine

2-Methylpyrazine
109-08-0

2-Methylpyrazine

2,5-dimethyl-pyrazine
123-32-0

2,5-dimethyl-pyrazine

2,3-dimethylpyrazine
5910-89-4

2,3-dimethylpyrazine

acetylpyrazine
22047-25-2

acetylpyrazine

2-ethyl-3,6-dimethylpyrazine
13360-65-1

2-ethyl-3,6-dimethylpyrazine

2,6-dimethylpyrazine
108-50-9

2,6-dimethylpyrazine

2,3,5-trimethylpyrazine
14667-55-1

2,3,5-trimethylpyrazine

2-ethyl-3,5-dimethylpyrazine
13925-07-0

2-ethyl-3,5-dimethylpyrazine

2-ethyl-5-methypyrazine
13360-64-0

2-ethyl-5-methypyrazine

Conditions
Conditions Yield
In water; at 130 ℃; for 2h; pH=8;

22047-25-2 Upstream products

  • 19847-12-2
    19847-12-2

    2-pyrazine carbonitrile

  • 75-16-1
    75-16-1

    methylmagnesium bromide

  • 290-37-9
    290-37-9

    1,4-pyrazine

  • 75-07-0
    75-07-0

    acetaldehyde

22047-25-2 Downstream products

  • 74476-22-5
    74476-22-5

    (E)-3-(3-Hydroxy-4-methoxy-phenyl)-1-pyrazin-2-yl-propenone

  • 74476-18-9
    74476-18-9

    (E)-3-(3-Ethoxy-4-hydroxy-phenyl)-1-pyrazin-2-yl-propenone

  • 74476-16-7
    74476-16-7

    (E)-3-(3-Ethoxy-2-hydroxy-phenyl)-1-pyrazin-2-yl-propenone

  • 74475-98-2
    74475-98-2

    (E)-3-(4-Chloro-phenyl)-1-pyrazin-2-yl-propenone

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