

Available forms:white to light yellow crystal powder
pd_proNo:373477-f7a1e5be-08ae-43f1-9c01-cbd96671091a
pd_productuse:
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Preparation |
2-Acetylthiazole is formed by oxidation of the corresponding carbinol using dichromate. |
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Synthesis Reference(s) |
The Journal of Organic Chemistry, 53, p. 1748, 1988 DOI: 10.1021/jo00243a029 |
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Purification Methods |
Check NMR spectrum; if it is not too bad, distil it through an efficient column in a vacuum. The oxime sublimes at 140-145o, m 159o, and when crystallised from H2O has m 163-165.5o. [Erlenmeyer et al. Helv Chim Acta 31 1142 1948, Waisvisz et al. J Am Chem Soc 79 4524 1957, Menasseé et al. Helv Chim Acta 40 554 1957, Beilstein 27 IV 2617.] |
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Aroma threshold values |
Detection at 4 ppb |
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Taste threshold values |
Taste characteristics at 30 ppm: corn chip with slightly musty background |
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General Description |
2-Acetylthiazole is a volatile flavoring substance generally formed by the Maillard reaction between an amino acid and carbonyl compounds. It is reported to occur in canned sweet corn products, cooked pine mushroom, cooked asparagus and roasted beef. |
InChI:InChI=1/C5H5NOS/c1-4(7)5-6-2-3-8-5/h2-3H,1H3
The role of amino acids and α-dicarbonyl...
Herein, a new procedure for the carbonyl...
The invention relates to a synthetic met...
The sulphur aroma compounds produced fro...
L-Cysteine
[1-13C]ascorbic acid
2,5-dihydro-thiophene
thiophene
2-Methylthiophene
4,5-Dimethylthiazole
4,5-Dihydro-2-methylthiophen-3-(2H)-on
2,4,5-trimethylthiazole
2-Acetylthiophene
2-Acetylthiazole
2-acetyl-3-methylthiophene
3-(vinylthio)thiophene
| Conditions | Yield |
|---|---|
|
at 140 ℃;
for 2h;
pH=8;
aq. phosphate buffer;
Sealed vessel;
|
L-Cysteine
ascorbic acid
2,5-dihydro-thiophene
thiophene
2-Methylthiophene
4,5-Dimethylthiazole
4,5-Dihydro-2-methylthiophen-3-(2H)-on
2,4,5-trimethylthiazole
2-Acetylthiophene
2-Acetylthiazole
2-acetyl-3-methylthiophene
3-(vinylthio)thiophene
| Conditions | Yield |
|---|---|
|
at 140 ℃;
for 2h;
pH=8;
aq. phosphate buffer;
Sealed vessel;
|
1,3-thiazole
ethylmagnesium bromide
(±)-1-(thiazol-2-yl)ethanol
thiazole-2-carboxylic acid ethyl ester
2-bromo-1-thiazol-2-yl-ethanone
(3S,4S,5S)-6-O-benzyl-4,5-O-isopropyliden-3,4,5,6-tetrahydroxy-1-(2-thiazolyl)-1-hexanone
(3R,4S)-4-Benzyloxy-4-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-3-hydroxy-1-thiazol-2-yl-butan-1-one
(3S,4R,5R)-4-O-Benzyl-5,6-O-isopropylidene-3,4,5,6-tetrahydroxy-1-(2-thiazolyl)-1-hexanone
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