

Available forms:white crystals or powder
pd_proNo:539055-5019d798-a747-48ab-9ae9-fb4c58f7275f
pd_productuse:
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Preparation |
Prepared by cyclization of α-amino ketones, which were produced by the reduction of isonitroso ketones to yield the dihydropyrazines, which are dehydrogenated with mercury(I) oxide or copper(II) sulfate or sometimes with atmospheric oxygen. |
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Purification Methods |
Distil pyrazine in steam and crystallise it from water. Purify also by zone melting. [Beilstein 23 H 91, 23 II 80, 23 III/IV 899, 23/5 V 351.] |
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General Description |
Pyrazine, also known as 1,4-diazine or p-diazine, is a heterocyclic aromatic compound characterized by a six-membered ring containing two nitrogen atoms at opposite positions. It is a key structural motif in various biologically active molecules and flavor compounds, often contributing to nutty, roasted, or earthy aromas in foods and beverages. Pyrazine derivatives are widely studied for their applications in pharmaceuticals, agrochemicals, and materials science due to their versatile chemical properties and ability to participate in diverse synthetic pathways. Pyrazine's stability and electron-rich nature make it a valuable scaffold in medicinal chemistry and functional materials. |
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Definition |
ChEBI: A diazine that is benzene in which the carbon atoms at positions 1 and 4 have been replaced by nitrogen atoms. |
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Aroma threshold values |
300 ppm (odor threshold in water) |
InChI:InChI=1/C4H4N2/c1-2-6-4-3-5-1/h1-4H
The role of amino acids and α-dicarbonyl...
The generation of pyrazines in a binary ...
Mixed oxides (mo)-ZnAl; NiAl; CoAl (M2+/...
Borohydride (BH4-)-containing coordinati...
3-amino-2-propanol
1,4-pyrazine
2-Methylpyrazine
2,5-dimethyl-pyrazine
2-ethyl-3,6-dimethylpyrazine
2,3,5-trimethylpyrazine
1-aminoethyl-2-methylaziridine
| Conditions | Yield |
|---|---|
|
With
copper chromite;
at 180 ℃;
for 0.333333h;
Product distribution;
var. temp.; other aminoalcohols;
|
D-glucose
H-Lys-Lys-OH hydrochloride
1,4-pyrazine
2-Methylpyrazine
2,5-dimethyl-pyrazine
2,3-dimethylpyrazine
2-ethyl-3,6-dimethylpyrazine
2,6-dimethylpyrazine
2,3,5-trimethylpyrazine
3-ethenyl-2,5-dimethylpyrazine
2-ethyl-6-methylpyrazine
| Conditions | Yield |
|---|---|
|
In
water;
at 130 ℃;
for 2h;
pH=8;
|
2-pyrazylcarboxylic acid
2,5-pyrazinedicarboxylic acid
2,3-dicarboxypyrazine
diethyl pyrazine-2,5-dicarboxylate
2-Butylpyrazine
1-phenethyl-pyrazinium; iodide
N-ethylpyrazinium iodide
1-phenacyl-pyrazinium; bromide
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