pyrazine

Available forms:white crystals or powder

pd_proNo:539055-5019d798-a747-48ab-9ae9-fb4c58f7275f

pd_productuse:

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Detailed introduction

Reliable Quality pyrazine 290-37-9 Hot Sale with Chinese Manufacturer

  • Molecular Formula:C4H4N2
  • Molecular Weight:80.0892
  • Appearance/Colour:white crystals or powder 
  • Vapor Pressure:19.7mmHg at 25°C 
  • Melting Point:50-56 ºC(lit.) 
  • Refractive Index:1.5235 
  • Boiling Point:118.634 ºC at 760 mmHg 
  • PKA:0.65(at 27℃) 
  • Flash Point:55.556 ºC 
  • PSA:25.78000 
  • Density:1.055 g/cm3 
  • LogP:0.47660 

Pyrazine(Cas 290-37-9) Usage

Preparation

Prepared by cyclization of α-amino ketones, which were produced by the reduction of isonitroso ketones to yield the dihydropyrazines, which are dehydrogenated with mercury(I) oxide or copper(II) sulfate or sometimes with atmospheric oxygen.

Purification Methods

Distil pyrazine in steam and crystallise it from water. Purify also by zone melting. [Beilstein 23 H 91, 23 II 80, 23 III/IV 899, 23/5 V 351.]

General Description

Pyrazine, also known as 1,4-diazine or p-diazine, is a heterocyclic aromatic compound characterized by a six-membered ring containing two nitrogen atoms at opposite positions. It is a key structural motif in various biologically active molecules and flavor compounds, often contributing to nutty, roasted, or earthy aromas in foods and beverages. Pyrazine derivatives are widely studied for their applications in pharmaceuticals, agrochemicals, and materials science due to their versatile chemical properties and ability to participate in diverse synthetic pathways. Pyrazine's stability and electron-rich nature make it a valuable scaffold in medicinal chemistry and functional materials.

Definition

ChEBI: A diazine that is benzene in which the carbon atoms at positions 1 and 4 have been replaced by nitrogen atoms.

Aroma threshold values

300 ppm (odor threshold in water)

InChI:InChI=1/C4H4N2/c1-2-6-4-3-5-1/h1-4H

290-37-9 Relevant articles

Characteristic flavor formation of thermally processed N-(1-deoxy-α-D-ribulos-1-yl)-glycine: Decisive role of additional amino acids and promotional effect of glyoxal

Zhan, Huan,Cui, Heping,Yu, Junhe,Hayat, Khizar,Wu, Xian,Zhang, Xiaoming,Ho, Chi-Tang

, (2021/09/28)

The role of amino acids and α-dicarbonyl...

Comparison of pyrazines formation in methionine/glucose and corresponding Amadori rearrangement product model

Cui, Heping,Deng, Shibin,Hayat, Khizar,Ho, Chi-Tang,Zhai, Yun,Zhang, Qiang,Zhang, Xiaoming

, (2022/03/07)

The generation of pyrazines in a binary ...

A comparative study on the catalytic activity of ZnAl, NiAl, and CoAl mixed oxides derived from LDH obtained by mechanochemical method in the synthesis of 2-methylpyrazine

Teodorescu,Slabu,Pavel,Z?voianu

, (2019/10/28)

Mixed oxides (mo)-ZnAl; NiAl; CoAl (M2+/...

Reactivity of borohydride incorporated in coordination polymers toward carbon dioxide

Kadota, Kentaro,Sivaniah, Easan,Horike, Satoshi

, p. 5111 - 5114 (2020/05/26)

Borohydride (BH4-)-containing coordinati...

290-37-9 Process route

3-amino-2-propanol
78-96-6,1674-56-2

3-amino-2-propanol

1,4-pyrazine
290-37-9

1,4-pyrazine

2-Methylpyrazine
109-08-0

2-Methylpyrazine

2,5-dimethyl-pyrazine
123-32-0

2,5-dimethyl-pyrazine

2-ethyl-3,6-dimethylpyrazine
13360-65-1

2-ethyl-3,6-dimethylpyrazine

2,3,5-trimethylpyrazine
14667-55-1

2,3,5-trimethylpyrazine

1-aminoethyl-2-methylaziridine

1-aminoethyl-2-methylaziridine

Conditions
Conditions Yield
With copper chromite; at 180 ℃; for 0.333333h; Product distribution; var. temp.; other aminoalcohols;
D-glucose
50-99-7

D-glucose

H-Lys-Lys-OH hydrochloride
134276-45-2

H-Lys-Lys-OH hydrochloride

1,4-pyrazine
290-37-9

1,4-pyrazine

2-Methylpyrazine
109-08-0

2-Methylpyrazine

2,5-dimethyl-pyrazine
123-32-0

2,5-dimethyl-pyrazine

2,3-dimethylpyrazine
5910-89-4

2,3-dimethylpyrazine

2-ethyl-3,6-dimethylpyrazine
13360-65-1

2-ethyl-3,6-dimethylpyrazine

2,6-dimethylpyrazine
108-50-9

2,6-dimethylpyrazine

2,3,5-trimethylpyrazine
14667-55-1

2,3,5-trimethylpyrazine

3-ethenyl-2,5-dimethylpyrazine
80935-98-4

3-ethenyl-2,5-dimethylpyrazine

2-ethyl-6-methylpyrazine
13925-03-6

2-ethyl-6-methylpyrazine

Conditions
Conditions Yield
In water; at 130 ℃; for 2h; pH=8;

290-37-9 Upstream products

  • 98-97-5
    98-97-5

    2-pyrazylcarboxylic acid

  • 122-05-4
    122-05-4

    2,5-pyrazinedicarboxylic acid

  • 89-01-0
    89-01-0

    2,3-dicarboxypyrazine

  • 103150-78-3
    103150-78-3

    diethyl pyrazine-2,5-dicarboxylate

290-37-9 Downstream products

  • 29460-91-1
    29460-91-1

    2-Butylpyrazine

  • 6274-01-7
    6274-01-7

    1-phenethyl-pyrazinium; iodide

  • 7466-71-9
    7466-71-9

    N-ethylpyrazinium iodide

  • 7477-71-6
    7477-71-6

    1-phenacyl-pyrazinium; bromide

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